The Saint Berdoodle carries several serious health considerations from the Saint Bernard side. Bloat (gastric dilatation-volvulus) is the most acute emergency risk in this deep-chested giant, and prophylactic gastropexy surgery is strongly recommended — discuss it with your vet. Dilated cardiomyopathy (DCM) is an elevated risk in Saint Bernard lines, so heart testing of the Saint Bernard parent is essential, and Von Willebrand's disease, a bleeding disorder, should be ruled out by DNA test. From the Poodle side, progressive retinal atrophy (PRA) should be screened by DNA test.
Hip dysplasia is a concern shared by both parent breeds, so both parents should be scored under the BVA/KC Hip Dysplasia Scheme. The Saint Berdoodle's lifespan of 10 to 12 years is typical of giant crossbreeds, and keeping the dog lean is one of the most effective things an owner can do for joint and heart health.