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Mastiffs are not inherently aggressive toward humans. They tend to be friendly and affectionate with family members but aloof and reserved with strangers, serving as effective watchdogs without unnecessary barking. Aggression, if it occurs, is typically due to poor socialisation or training. With proper upbringing, Mastiffs remain gentle and protective rather than aggressive.

Mastiffs have a calm, patient, and affectionate temperament. They are slow to respond but eager to please, known as gentle giants who are loyal and devoted. Mastiffs are generally good with other pets and children when socialised early, have low to moderate energy levels, and tend to be aloof with strangers, which makes them natural guardians.

While both are very large breeds, Mastiffs are typically heavier and bulkier with a massive frame, whereas Great Danes are taller and leaner. Mastiffs have more body mass and weight, making them appear more massive overall, while Great Danes have a more athletic and slender build.