Cat colour genetics plays a fascinating role in determining the wide array of coat colours and patterns seen in domestic cats. The primary colour genes in cats are responsible for black, red (orange), and white, while additional modifier genes influence the distribution and dilution of these colours. Understanding these genetic mechanisms helps explain why litters can display such diverse coat colours.
Two key pigments govern cat coat colour: eumelanin (black/brown pigment) and phaeomelanin (red/orange pigment). The expression of these pigments is controlled by several genes, notably the OCA2, B, and Agouti genes. Specific genes like MC1R affect whether black or red pigment is produced. The dilution gene (D) modifies black to blue, red to cream, and chocolate to lilac.
Beyond base colour, cats have genes controlling patterns such as tabby stripes, colourpoints (as in Siamese), and tortoiseshell coats. Tortoiseshell and calico patterns arise from X-chromosome linkage, explaining why nearly all such cats are female. The MC1R gene regulates red pigment expression, while the Ty gene determines pattern types including classic tabby, mackerel, spotted, and ticked. Modifier genes further influence exact expression of these patterns.
Genetic inheritance in cats follows Mendelian principles with additional complexities due to sex-linked traits and multiple alleles. Predicting litter colours is achievable with knowledge of both parents' genetics, though complex modifier genes can still produce surprises. A solid-coloured cat carries two copies of the non-agouti gene, while tabbies carry at least one agouti gene. Carrier animals may show no outward sign of the genes they carry, contributing further to the variability seen in offspring.
Other genes control whether a cat displays pointed, smoke, or shaded patterns, which affect where colour is distributed along individual hair shafts. White spotting and full white coats involve separate genetic pathways, with associated health considerations, such as deafness linked to certain white coat genes. Further colour modifiers include additional genes responsible for other colours. Breeders and geneticists continue to expand understanding of cat colour genetics, revealing an intricate tapestry of hereditary factors shaping the beautiful diversity seen in domestic cats today.