Complete Guide to Lundehund Syndrome DNA Testing for Norwegian Lundehunds

The Norwegian Lundehund puppies are a unique and fascinating breed known for their remarkable agility and history. Originating from Norway, these small spitz-type dogs have a special place due to their unique traits and some hereditary health issues, notably Lundehund syndrome. This comprehensive guide will explain this syndrome in detail and show you how to get your Lundehund DNA tested in the UK as of 2025.

Understanding Lundehund Syndrome or Lymphangiectasia

Lundehund syndrome (LS), also called lymphangiectasia, is a hereditary gastrointestinal disorder affecting Norwegian Lundehunds. It involves a cluster of conditions such as protein-losing enteropathy, chronic gastroenteropathy, and bacterial overgrowth in the intestine. This leads to poor nutrient absorption, vomiting, diarrhoea, and weight loss.

The syndrome stems from an autosomal recessive mutation in the LEPREL1 gene, meaning a dog must inherit the faulty gene copies from both parents to be affected. Signs of LS often emerge between the ages of 6 months and 10 years. Sadly, chronic inflammation from LS can result in serious complications, including lymphoma, intestinal cancer, and organ perforation.

Current veterinary consensus in the UK for 2025 emphasises genetic testing and responsible breeding as key to controlling LS, alongside careful clinical management to support affected dogs' welfare.

How is Lundehund Syndrome Inherited?

LS follows an autosomal recessive inheritance pattern. Each puppy’s status depends on the genetic status of both parents. There are three possible statuses:

• Clear: The dog carries no mutations and will not develop or pass on LS.
• Carrier: The dog carries one mutated gene and can pass LS to offspring but is usually healthy.
• Affected: The dog inherits two mutated genes and will likely develop LS.

Possible breeding outcomes based on mating pairs:

• Two clear dogs produce only clear puppies.
• Two affected dogs produce all affected puppies.
• Carrier × Carrier mating results in a litter with roughly 25% clear, 50% carriers, and 25% affected puppies.
• Clear × Carrier mating results in 50% clear and 50% carrier puppies.
• Carrier × Affected mating produces 50% carrier and 50% affected puppies.
• Clear × Affected mating results in all carrier puppies.

Step-by-Step Guide: How to Get Your Norwegian Lundehund DNA Tested for Lundehund Syndrome in the UK (2025)

Step 1: Book a Vet Consultation

Contact your local veterinary practice and schedule an appointment to discuss DNA testing for Lundehund syndrome. Inform them specifically about the test to ensure they prepare accordingly.

Step 2: DNA Sample Collection

Your vet will collect a DNA sample, most commonly via a cheek swab. Occasionally, a blood sample might be requested. This procedure is simple, quick, and painless for your dog.

Step 3: Sample Submission to an Approved Laboratory

The veterinarian will send the DNA sample to an accredited UK or international laboratory approved for Lundehund syndrome testing. These labs test for the mutation (c.1849G>C in the P3H2 gene) responsible for LS.

Step 4: Laboratory Analysis

The lab analyses the DNA to determine whether your Lundehund is clear, a carrier, or affected. Results typically come back within a few weeks.

Step 5: Receive and Interpret Results

You will receive a detailed report via your vet outlining your dog's genetic status. Use this information responsibly for breeding decisions or monitoring your dog's health.

Step 6: Responsible Breeding and Health Management

For breeders, avoid mating two carriers or affected dogs to prevent affected puppies. If your dog is affected, work closely with your vet to manage symptoms via diet and supportive care, as no cure currently exists. Early diagnosis leads to better health outcomes.

Considerations for Responsible Norwegian Lundehund Ownership and Breeding

Given the breed's limited genetic diversity due to historical bottlenecks, managing Lundehund syndrome requires careful breeding strategies. Some breeders have started outcrossing with related breeds under guidance to increase diversity while maintaining breed characteristics.

Owners and potential buyers should always seek reputable breeders who perform health testing and are transparent about their dogs' genetic status.

Conclusion

Lundehund syndrome is a significant inherited health issue in the Norwegian Lundehund breed, requiring genetic testing and responsible breeding to manage. By following the accessible DNA testing process through your vet and applying breeding recommendations, you can help reduce LS prevalence and protect your dog’s wellbeing for years to come.