Multisystem chromatolytic neuronal degeneration (MCND) is a rare and serious inherited neurological disorder affecting Cairn Terriers. This progressive condition involves widespread degeneration of neurons throughout the nervous system, including the brain, spinal cord, and sensory ganglia, which significantly impacts the dog's mobility and quality of life.
MCND primarily affects motor neurons, responsible for transmitting impulses that enable muscle movement. In affected Cairn Terriers, these essential nerve signals fail to reach muscles properly, causing muscle stiffness, weakness, and eventually an inability to stand due to progressive loss of muscle control. This disorder typically appears in puppies, often as early as 11 weeks of age, and worsens over time.
While the disorder is inherited, the exact genetic mechanism and metabolic cause remain unknown. Research continues to investigate why Cairn Terriers are particularly predisposed to this form of neurodegeneration, compared to other breeds.
Symptoms can range from mild to severe and commonly include:
A veterinary neurologist will evaluate a dog's full medical history and conduct a thorough neurological examination. Diagnostic tests may include:
Diagnosis is challenging and often relies on ruling out other neurological diseases alongside clinical signs and test results.
Unfortunately, there is no known cure or effective treatment for MCND. The disorder's progressive nature means symptoms will worsen over time, leading to significant mobility impairment and affecting quality of life.
Supportive care, including managing mobility and comfort, is vital. Humane euthanasia is often considered in severe cases to prevent unnecessary suffering, with decisions made compassionately in consultation with veterinary professionals.
Because MCND is inherited, responsible breeding practices are essential to reduce its incidence. Dogs diagnosed with any degree of the disorder should be spayed or neutered and excluded from breeding programmes. Furthermore, breeding dogs from lines with a history of MCND should be monitored and ideally not bred until they are at least three years old. This allows time for the identification of carriers or affected individuals before breeding decisions are made.
Potential breeders and owners should work with reputable breeders who follow health screening protocols to help safeguard this breed's future health.
Multisystem chromatolytic neuronal degeneration is a rare but severe inherited neurological condition in Cairn Terriers that leads to progressive motor weakness, muscle atrophy, and coordination difficulties. Despite the lack of treatment, early recognition and responsible breeding practices are crucial to managing this disease and preventing its spread. Owners and breeders should consult veterinary specialists for diagnosis and support, always prioritising the welfare of affected dogs.