This article is part of a detailed series on cat genetics. If you have not yet read part one, we recommend starting there to understand DNA and genes before continuing.
Every kitten inherits half of its genetic makeup from its mother and half from its father, but due to chromosomal swapping during reproduction, each individual cat has a unique genetic profile. This genetic reshuffling means that even though the DNA comes exclusively from the parents, the combination is entirely new and varies significantly.
Maintaining a large gene pool is vital for the health of cat breeds. It's not enough for a breed to have many individuals; what truly matters is the diversity of genetic material. Many cat breeds started from a mutation in a single individual, such as the American Curl, which began with one cat exhibiting curled ears. Responsible breeders introduced outcrosses from domestic or similar breeds to expand the gene pool and reduce health issues.
In contrast, some established breeds like the Ragdoll in the UK began from few founder cats, leading to a limited gene pool and potential inbreeding issues. Similarly, the Burmese breed demonstrates how a restricted gene pool can exist despite a large population, underscoring the importance of careful pedigree research by buyers and breeders alike.
Not necessarily. Inbreeding occurs naturally in cats, especially in uncontrolled local populations where dominant males often mate with related females. This can lead to close relatives breeding, which increases the chance of recessive traits appearing in offspring. While selective inbreeding is used by show breeders to fix particular desirable traits, such as specific coat colours or shapes, this must be carefully managed to avoid the emergence of harmful recessive conditions.
Some health conditions and traits in cats are caused by dominant genes, meaning they can manifest even if only one copy is present. For example, Polycystic Kidney Disease (PKD) in Persian cats is caused by a dominant gene—only one copy from one parent is needed to cause the condition. This explains why it has spread so widely, even among responsible breeders. To combat this, genetic tests are available, and breeding from cats who test negative can effectively eliminate PKD from future litters.
Today, breeders benefit from genetic testing to identify carriers of harmful recessive conditions, allowing them to make informed decisions about pairings. By testing cats for known mutations and avoiding mating two carriers, breeders can significantly reduce the incidence of disease in offspring. This approach benefits not only individual cats but also helps to maintain or improve the genetic health of entire breeds over time.
Understanding how inheritance works in cats helps both breeders and owners make better decisions for the welfare of their cats. Whether you are researching a health condition or simply curious about your cat’s traits, genetics provides insight into what makes each cat unique.